Download e-book for kindle: Advances in Medicinal Chemistry: 4 by B. E. Maryanoff,A. B. Reitz

By B. E. Maryanoff,A. B. Reitz

quantity four of Advances in Medicinal Chemistry is constructed from six chapters on quite a lot of subject matters in medicinal chemistry, together with molecular modeling, structure-based drug layout, natural synthesis, peptide conformational research, organic evaluation, structure-activity correlation, and lead optimization. bankruptcy 1 offers an account approximately amino acid-based peptide mimetics such as b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. bankruptcy 2 addresses new features of the medicinal chemistry of the $64000 anticancer drug Taxol® (paclitaxel). bankruptcy three relates an account of the quest for brand spanking new medicinal drugs for the remedy of malaria in response to the common product artemisinin. bankruptcy four applies computational chemistry to the review of compound libraries for organic checking out. bankruptcy five describes the development of a three-d molecular version of the human thrombin receptor, the 1st protease-activated G-protein coupled receptor (PAR-1), as a method to discover the intermolecular contacts interested by agonist peptide popularity. ultimately, bankruptcy 6 describes the study performed at Merck on inhibitors of farnesyl transferase as a possible therapy for human cancers.

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Advances in Medicinal Chemistry: 4 by B. E. Maryanoff,A. B. Reitz

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